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Melasma is a common form of hyperpigmentation that causes patchy brown, tan, or gray discoloration, usually on the face

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For example, addition of exogenous complex I substrates, such as glutamate plus malate, or α-KG, significantly augmented NADH levels and mitochondrial membrane potential, which stimulated H 2 O 2 production by ∼10-fold in isolated rat brain mitochondria (95)